Endocrine Abstracts

Introduction: Reduced bone mineral density (BMD) is present in many women with Turner syndrome (TS), while hypo-estrogenism is known to play a vital role in bone mineralization disturbances. It has been suggested that genetic factors play an important role in the regulation of BMD. The aim of this study was to analyze the association between PvuII and XbaI ER-a polymorphisms and BMD in TS patients subjected to estroprogestagen (EP) treatment.Material and...

Introduction: The aim of this study was to verify if genetic factors influence the short- and long-term therapeutic responses to oestroprogestagen (OP) therapy, implemented in girls with functional hypothalamic amenorrhoea (FHA) in order to improve their bone mineral density (BMD).Material and methods: The study included 84 FHA girls who underwent a 4-year sequential OP therapy with 17-β oestradiol and didrogesterone. Changes in the lumbar spine BMD...